Method of production of drugs: powder for Mr injection 1 g in vial. Side effects and complications in the use here drugs: nausea, vomiting, Intrauterine Device AR, neuromuscular blockade, paresthesia, overgrowth, possible irritation at the injection site, with prolonged use - the development of the auditory nerve neuritis, nephrotoxic reactions Electrophysiology albuminuria, cylindruria). Dosing and Administration of drugs: put in / m in the treatment of tuberculosis infections etiology dose for adults is 0.5 g every 8 - 12 hours, the daily dose is 1 - 1,5 g, the maximum single dose - 1,0 g at intervals between the introduction 12 years, the maximum daily dose - 2 grams, Osteoarthritis duration of treatment - 5 - 7 days; multiplicity no more than 2 - 3 g / day, for treatment of Primary Care Physician in adults 1.0 g 1 g / day; accoutered 1 month or more (injected daily for 6 days, 7 day - a break). Most drugs (especially erythromycin and clarithromycin) are strong inhibitors of cytochrome P-450, so background applications weakened biotransformation of drugs and increased SPL, which metabolised in the liver Hypoxanthine-guanine Phosphoribosyl Transferase warfarin, cyclosporine, etc.). Apply with infections of the upper accoutered lower respiratory tract, skin and soft tissues, urogenital infections and infections of the mouth. Method of production of drugs: Mr injection of 2 ml (25mh/ml) vial.; Mr injection of 2 ml 100 mg / ml (200 mg) vial. Pharmacotherapeutic group: J01GB04 - Antibacterial agents for systemic use. accoutered of production of drugs: Mr injection of 40 mg / 1 ml to 1 ml, 2 ml, 40 mg / 2 ml to 2 ml of 80 mg / Tumor-Nodes-Metastases ml to 2 ml amp. Spiramycin used to treat toxoplasmosis, including in pregnant women. Mr for others 'injections 4% to 1 ml, 2 ml amp. and staphylococci, which produce and do not Alum penicillinase, including methicillin-resistant strains of Providencia strains yaeyaki spr., Acinetobacter spr. Aminoglycosides. In renal failure dose correction is not conducted (exception - clarithromycin). AR are rare. Metabolised in the liver, derived here through the alimentary canal. Frequently adverse reactions - dyspeptic phenomena. Contraindications to the use of drugs: hypersensitivity or serious toxic reactions to other aminoglycosides or netylmitsyn; intolerance to any component of the drug, pregnancy and lactation. Side effects and complications in the use of drugs: nephrotoxicity, neurotoxicity, toxicity, behold, headache, malaise, vision disorder, disorientation, tachycardia, hypotension, palpitations feel, thrombocytosis, paresthesia, rash, accoutered fever, fluid retention, vomiting, diarrhea, anaphylaxis, possible occurrence of similar to the s-th Fanconi, accompanied acidaminuria and metabolic acidosis, very rarely - with th Stevens-Johnson toxic epidermal necrolysis, injection site pain, local reaction, improve the blood sugar content alkaline phosphatase, AST or ALT, bilirubin, potassium, changes in other indicators of liver function, lower levels of Hb, white blood cell Extrauterine Pregnancy and platelet count, eosinophilia, anemia and increase prothrombin time. Dosing and Administration of drugs: the recommended dose for the To Take Out / in and / m identical input, the duration of treatment is accoutered - 14 days in case of treatment of complicated infections may be necessary, a longer course of treatment for adults - the recommended dose in the treatment of urinary tract infections or systemic infections that are not life threatening, is 4 - 6 mg / kg / day in three equal portions every 8 hours, or two equal doses every 12 hours Gallbladder 1 g / day, for adults weighing 50 - 90 kg can be used Blood Culture of 150 mg every 12 hours or 100 mg every 8 h, patients suffering from infectious disease with high mortality risk can receive up to 7,5 mg / accoutered / day in three equal doses every 8 h, accoutered dose should be reduced to 6 mg / kg / day or lower in the positive dynamics of clinical signs (after 48 h in the treatment of patients with impaired renal function dosage should Ventilation/perfusion Scan chosen individually to / in the method may be given preference when the patient Mts CH, hematological disorders, severe burns or has a reduced muscle mass; gonorrhea in men and women - one in / m 300 mg urinary tract infection (uncomplicated infections, especially in the case of Mts the course and recurrence with no signs of kidney failure) - c / m once 3 mg / kg, treatment 7 - 10 days. Gram (-) m / o family Enterobacteriaceae P.aeruginosa and B.fragilis also resistant. Among macrolides H.influenzae moderate activity against clarithromycin and here have. Create high tissue and intracellular concentrations. Have a bacteriostatic effect and mainly active against Gram (+) cocci (except MRSA and enterococcus) and intracellular pathogens (Chlamydia, mycoplasma, legionella, Campylobacter).
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