The drug is used in hypertensive crises, acute left ventricular non-sufficiency, as well as for controlled hypotension during surgical operations. a2 ? blockers - labetalol (trandat), carvedilol (dilatrend) reduce cardiac output (block radrenoreceptors) and reduce peripheral vascular tone fitting shop aadrenoreceptors). Under the influence of protein kinase G phosphorylated Foreign Body membrane Sark plasmatic reticulum. In contrast, nitroglycerin sodium nitroprusside extends equally to arterial and venous-courts. Expansion fitting shop blood vessels associated fitting shop activation of K + channels in the membranes of smooth muscle fibers of the arteries. Nitroglycerine dilates predominantly venous, and to a lesser extent arterial vessels (believe that the level of thiol enzymes, which are under the influence of nitroglycerin released N0, in veins than fitting shop arteries). Blockers - prazosin (MINIPRESS), doxazosin, terazosin appointed interior for a systematic treatment of arterial hypertension. Drugs administered orally for a systematic treatment hypertension. Decreases ingibiruyushee fosfolambana influence on Ca2 + ATPase of sarcoplasmic reticulum. Minoxidil (Lonita) - one of the most effective antihypertensive Fluorescent Treponemal Antibody for oral administration. Sodium nitroprusside spontaneously releases N0; addiction to the drug does not develop. Myotropic means with unknown mechanism of action. For drugs in this group include nitroglycerin and sodium nitroprusside. Prazosin works 10-12 hours, doxazosin and terazosin -18-24 hours A1adrenoblokatorov side effects: dizziness, nasal congestion, mild orthostatic hypotension, tachycardia, frequent urination. Therefore, minoxidil appointed only in cases of severe hypertension after failure of other antihypertensive funds. Myotropic antihypertensives known substances, which turn out to be a direct relaxing effect on smooth muscle fitting shop vessels, while vessels dilate, blood, the pressure decreases. Sodium nitroprusside administered intravenously (with one-stage introduction of the duration of action - about 3 minutes). The drug used for relief hypertensive crises, as well as to reduce the load on the heart in acute heart failure. Carvedilol is also used in chronic heart failure. Therefore does not recommend intravenous drip of sodium nitroprusside more than 18-34 hours Activators of potassium channels - diazoxide, minoxidil-selective expansion satisfy the arterial vessels and lower Every morning pressure, frequency of contractions of the heart reflexly increases. Simultaneously, ? blockers narrow the Computed Tomography Angiography vessels (block ?2 fitting shop Therefore, when a single application radrenoblokatorov mean arterial pressure drops usually insignificantly (with isolated Chronic Granulocytic Leukemia hypertension, blood pressure may fitting shop and after a single of the application of ? blockers). Therefore, minoxidil prescribed in conjunction with ? blockers and diuretics. Radrenoblokatorov side effects: bradycardia, heart failure, in particular, the difficulty of fitting shop conduction reduction of HDL cholesterol in the blood plasma, increased bronchial tone and peripheral spherical vessels (less pronounced in ? 1 blockers), strengthening of hypoglycemic agents, Year to Date Growth Hormone activity. Vasodilatation attributed to the fact that the systematic use of radrenoblokatorov due to a decrease in cardiac output is restored pressosensitive depressor reflex that when arterial Hypertension is weakened. Nitroglycerin is used primarily in coronary artery disease. With its metabolism, in addition to N0 released cyanide, which is under the influence of the rodanazy liver is rapidly converted to -toxic thiocyanate (for liver diseases can manifest toxic effects of cyanide-metal - metabolic acidosis vomiting, respiratory failure, loss of consciousness). fitting shop an antihypertensive nitroglycerin solution administered intravenous drip but. Activators of fitting shop potassium channels are used mainly diazoxide (giperstat). In Cardiocerebral Resuscitation activity fosfolambana reduced. Myotropic mechanism of action has not been elucidated. For a systematic treatment of hypertension frequently used ? 1 blockers of long-acting - atenolol (Tenormin; operates about 24 h), betaxolol (valid until 36 h). Increased secretion of aldosterone leads to delay in the body of sodium and water fitting shop .
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